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chairman Wenlin Huang

CHAIRMAN MESSAGE

Gene therapy is an emerging treatment technology and biologics developed in the 1990s on the basis of human and disease genomics, and is an important part of precision medicine. The principle is to use the normal genes of the human body to replace mutated or silenced genes to treat diseases caused by single-gene or multi-gene mutations, including diabetes, cardiovascular diseases, tumors, and rare diseases in children. On the way to precision medicine, we have a bright vision and a long way to go. We also need to continuously absorb new technologies, carry out effective integration of production, education and research, and provide high-quality biomedical products to the market. Currently, the company is working on projects such as  anti-angiogenesis, tumor transcription, immune rebalance and cell cycle pigment, radiotherapy protection products, forming a series of new research and development products targeting on the key microenvironment of tumor production.

 

The company's mission is to use modern gene technology and targeting vectors as a platform, aiming at the key driver genes of human tumorigenesis, through prospective research of big data and multi-center clinical trials, to develop new genetic biologics with unique targets . It is our goal to improve the survival rate and quality of life of cancer patients, and to allow cancer patients to enjoy the therapeutic results brought by new technologies in the 21st century.

On behalf of all the members of Doublle Bioproduct Co., Ltd., I wish that the human health  enters a new era to overcome cancers!






CHAIRMAN INTRODUCED

Dr. Huang Wenlin, Chairman of the Company, Oncologist, Expert of National New Drug Evaluation Center, Consultant of 973 Infectious Diseases of the Ministry of Science and Technology, Vice President of Gene Therapy Society of China Biomedical Association , Professor of Sun Yat-Sen University Cancer Center, Honorary Professor of The Chinese University of Hong Kong, and a leading talent in innovation and entrepreneurship in Guangzhou.


He studied and then worked in Princeton University, Medical College of Pennsylvation, Advanced Viral Research Institute in the United States from 1988 to 2001, and returned to China in 2001 as a professor at Sun Yat-sen University Cancer Center. He has invented for 24 Chinese, American and international patents, among which the recombinant human endostatin adenovirus (E10A) injection,  a first in class new biologics in its kind, has entered the phase III clinical trial (approval number: 2012L02744). He has published more than 100 papers in internationally renowned SCI journals such as Nat Med, PNAS, JCI, JVI, JI, Mol Ther, Biomaterials, etc. In addition, he was the editor-in-chief of the national postgraduate textbooks "Molecular Virology", "Signal Transduction", "Tumour Molecular Targeted Therapy", "Melanoma", etc. He has successively won the title of the top ten outstanding overseas scholars of the Ministry of Education, the 12th National Gold Award for Chinese Invention Patent, the National Science and Technology Progress Award, the first prize of Natural Science of the Ministry of Education, the first prize of Chinese Medicine Award and the first prize of Guangdong Science and Technology Award, etc.




Certificate Of Honor

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AUTHORIZED INVENTION PATENT

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AUTHORIZED INVENTION PATENT

  • Huang Wenlin (Editor)：

    National graduate textbook "molecular virology" (Third Edition), people's Medical Publishing House, 2016.

  • Huang Wenlin (Editor)：

    Tumor molecular targeted therapy, people's Medical Publishing House, 2009

  • Huang Wenlin, Zhu Xiaofeng (editor in chief)：

    Signal transduction and disease (Second Edition), people's Medical Publishing House, 2012.

  • Huang Wenlin (Editor)：

    The principle of individualized medicine, people's Medical Publishing House, 2013.

  • Zhang Xiaoshi, Chen Yingbo, (editor in chief), (in Chinese)：

    Basic and clinical application of melanoma, people's Medical Publishing House, 2010.

  • Mai Haiqiang, Huang Wenlin (editor in chief)：

    "The miracle of biological pharmacy: the birth and development of gene drugs", Guangdong science and Technology Press, 2011.

THE POST LIST

1.         Liu T, Wu X, Li Y, Lu W, Zheng F, Zhang C, Long Q, Qiu H, Li Y, Ge Q, Chen M, Yu X, Chen W, Zhang H, Huang W, Luo M, Deng W, Li L. RBFOX3 Regulates the Chemosensitivity of Cancer Cells to 5-Fluorouracil via the PI3K/AKT, EMT and Cytochrome-C/Caspase Pathways. Cell Physiol Biochem. 2018 Apr 18;46(4):1365-1380.

2.         Shuai W, Wu J, Chen S, Liu R, Ye Z, Kuang C, Fu X, Wang G, Li Y, Peng Q, Shi W, Li Y, Zhou Q, Huang W. SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter. Cancer Lett. 2018 May 28;422:56-69.

3.         Li Y, Ye Z, Chen S, Pan Z, Zhou Q, Li YZ, Shuai WD, Kuang CM, Peng QH, Shi W, Mao X, Liu RY, Huang W. ARHGEF19 interacts with BRAF to activate MAPK signaling during the tumorigenesis of non-small cell lung cancer. Int J Cancer. 2018 Apr 1;142(7):1379-1391.

4.         Ye W, Ling S, Liu RY, Pan ZZ, Wang G, Gao S, Wu J, Cao L, Dong L, Li Y, ZhouY, Du W, Meng X, Chen J, Guan X, He Y, Pan C, Zheng XS, Lu X, Chen S, Huang W. Exome sequencing reveals the genetic landscape and frequent inactivation of PCDHB3 in Chinese rectal cancers. J Pathol. 2018 Mar 14: doi.

5.         Qiu L, Tan X, Lin J, Liu RY, Chen S, Geng R, Wu J, Huang W. CDC27 Induces Metastasis and Invasion in Colorectal Cancer via the Promotion of Epithelial-To-Mesenchymal Transition. J Cancer. 2017 Aug 21;8(13):2626-2635.

6.         Wu J, Tan X, Lin J, Yuan L, Chen J, Qiu L, Huang W. Minicircle-oriP-miR-31 as a Novel EBNA1-Specific miRNA Therapy Approach for Nasopharyngeal Carcinoma. Hum Gene Ther. 2017 May;28(5):415-427.

7.         Gao S, Li J, Song L, Wu J, Huang W. Influenza A virus-induced downregulation of miR-26a contributes to reduced IFNα/β production. Virol Sin. 2017 Aug;32(4):261-270.

8.         Lin J, Tan X, Qiu L, Huang L, Zhou Y, Pan Z, Liu R, Chen S, Geng R, Wu J, Huang W. Long Noncoding RNA BC032913 as a Novel Therapeutic Target for Colorectal Cancer that Suppresses Metastasis by Upregulating TIMP3. Mol Ther Nucleic Acids. 2017 Sep 15;8:469-481.

9.         Shi W, Ye Z, Zhuang L, Li Y, Shuai W, Zuo Z, Mao X, Liu R, Wu J, Chen S,Huang W. Olfactomedin 1 negatively regulates NF-κB signalling and suppresses the growth and metastasis of colorectal cancer cells. J Pathol. 2016 Nov;240(3):352-365.

10.     Yao C, Sheng C, Liu D, Gao S, Jiang W, Yu H, Li J, Chen H, Wu J, Pan C, Chen  S, Huang W. [Expression, purification of recombinant human cryptochrome I and its application in preparation of protective agent for radiotherapy]. Sheng Wu Gong Cheng Xue Bao. 2015 Jan;31(1):135-46.

11.     Wang L, Xu Y, Luo C, Sun J, Zhang J, Lee MW, Bai A, Chen G, Frenz CM, Li Z, Huang W. MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A 0201 alleles. Cell Immunol. 2015 Sep;297(1):10-8.

12.     Liu D, Sheng C, Gao S, Yao C, Li J, Jiang W, Chen H, Wu J, Pan C, Chen S,Huang W. SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity. Mol Cell Biol. 2015 Jul;35(14):2400-13.

13.     Liu J, Wu J, Zhou L, Pan C, Zhou Y, Du W, Chen JM, Zhu X, Shen J, Chen S, Liu RY, Huang W. ZD6474, a new treatment strategy for human osteosarcoma, and its potential synergistic effect with celecoxib. Oncotarget. 2015 Aug 28;6(25):21341-52.

14.     Chen H, Gao S, Li J, Liu D, Sheng C, Yao C, Jiang W, Wu J, Chen S, Huang W.Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer. Oncotarget. 2015 May 30;6(15):13049-59.

15.     Gao S, Wu J, Liu RY, Li J, Song L, Teng Y, Sheng C, Liu D, Yao C, Chen H,Jiang W, Chen S, Huang W. Interaction of NS2 with AIMP2 facilitates the switch from ubiquitination to SUMOylation of M1 in influenza A virus-infected cells. J Virol. 2015 Jan;89(1):300-11.

16.     Li J, Song L, Zhou L, Wu J, Sheng C, Chen H, Liu Y, Gao S, Huang W. A MicroRNA Signature in Gestational Diabetes Mellitus Associated with Risk of Macrosomia. Cell Physiol Biochem. 2015;37(1):243-52.

17.     Wu Q, Huang W. [Producing Ad-IFN gamma by suspension culture of HEK293 cells in a disposable bioreactor]. Sheng Wu Gong Cheng Xue Bao. 2014 Nov;30(11):1786-90.

18.     KatsuyukiHamada，ToshiroShirakawa，ShujiTerao，AkinobuGotoh，KenzaburoTani，HuangW. Biosafety studies of carrier cells infected with a replication-competent adenovirus introduced by IAI 3B promoter. Mol Ther Methods Clin Dev. 2014 May 28;1:14019.

19.     Liu D, Sheng C, Gao S, Jiang W, Li J, Yao C, Chen H, Wu J, Chen S, Huang W. eEF1Bγ is a positive regulator of NF-кB signaling pathway. Biochem Biophys Res Commun. 2014 Apr 4;446(2):523-8.

20.     Ye W, Liu R, Pan C, Jiang W, Zhang L, Guan Z, Wu J, Ying X, Li L, Li S, Tan W, Zeng M, Kang T, Liu Q, Thomas GR, Huang M, Deng W, Huang W. Multicenter randomized phase 2 clinical trial of a recombinant human endostatin adenovirus in patients with advanced head and neck carcinoma. Mol Ther. 2014 Jun;22(6):1221-1229.

21.     Wang L, Gao S, Jiang W, Luo C, Xu M, Bohlin L, Rosendahl M, Huang W. Antioxidative dietary compounds modulate gene expression associated with apoptosis, DNA repair, inhibition of cell proliferation and migration. Int J Mol  Sci. 2014 Sep 15;15(9):16226-45.

22.     Zhou Y, Wu J, Fu X, Du W, Zhou L, Meng X, Yu H, Lin J, Ye W, Liu J, Peng H, Liu RY, Pan C, Huang W. OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer. Mol Cancer. 2014 Nov 28;13:258.

23.     Yu H, Ye W, Wu J, Meng X, Liu RY, Ying X, Zhou Y, Wang H, Pan C, Huang W. Overexpression of sirt7 exhibits oncogenic property and serves as a prognostic factor in colorectal cancer. Clin Cancer Res. 2014 Jul 1;20(13):3434-45.

24.     Liu RY, Peng JL, Li YQ, Huang BJ, Lin HX, Zhou L, Luo HL, Huang W.Tumor-specific cytolysis caused by an E1B55K-attenuated adenovirus in nasopharyngeal carcinoma is augmented by cisplatin. Anat Rec (Hoboken). 2013Dec;296(12):1833-41.

25.     Xie FJ, Zhao P, Zhang YP, Liu FY, Nie XL, Zhu YH, Yu XM, Zheng QQ, Mao WM,Lu HY, Wei H, Huang W. Adenovirus-mediated interferon-γ gene therapy induced human pancreatic carcinoma Capan-2 cell apoptosis in vitro and in vivo. Anat Rec (Hoboken). 2013 Apr;296(4):604-10.

26.     Ying X, Wu J, Meng X, Zuo Y, Xia Q, Chen J, Feng Y, Liu R, Li L, Huang W. AC133 expression associated with poor prognosis in stage II colorectal cancer. Med Oncol. 2013 Mar;30(1):356.

27.     Li LX, Zhang YL, Zhou L, Ke ML, Chen JM, Fu X, Ye CL, Wu JX, Liu RY, Huang W.Antitumor efficacy of a recombinant adenovirus encoding endostatin combined with an E1B55KD-deficient adenovirus in gastric cancer cells. J Transl Med. 2013 Oct 14;11:257.

28.     Chen S, Sheng C, Liu D, Yao C, Gao S, Song L, Jiang W, Li J, Huang W. Enhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses. J Immunol. 2013 Sep 1;191(5):2614-23.

29.     Yu H, Meng X, Wu J, Pan C, Ying X, Zhou Y, Liu R, Huang W. Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer. PLoS One. 2013 Apr 23;8(4):e61679.

30.     Jiang W, Wang Q, Chen S, Gao S, Song L, Liu P, Huang W. Influenza A virus NS1 induces G0/G1 cell cycle arrest by inhibiting the expression and activity of RhoA protein. J Virol. 2013 Mar;87(6):3039-52.

31.     Meng X, Wu J, Pan C, Wang H, Ying X, Zhou Y, Yu H, Zuo Y, Pan Z, Liu RY, Huang W. Genetic and epigenetic down-regulation of microRNA-212 promotes colorectal tumor metastasis via dysregulation of MnSOD. Gastroenterology. 2013 Aug;145(2):426-36.

32.     Liu RY, Zhu YH, Zhou L, Zhao P, Li HL, Zhu LC, Han HY, Lin HX, Kang L, Wu JX, Huang W. Adenovirus-mediated delivery of interferon-γ gene inhibits the growth of nasopharyngeal carcinoma. J Transl Med. 2012 Dec 28;10:256.

33.     Wang Q, Chen Y, Gao S, Jiang W, Song L, Huang W. [Immunological efficiency induced by HIV-1 p24 DNA combined with P24 protein]. Sheng Wu Gong Cheng Xue Bao. 2011 May;27(5):773-80.

34.     Zuo Y, Wu J, Xu Z, Yang S, Yan H, Tan L, Meng X, Ying X, Liu R, Kang T,Huang W. Minicircle-oriP-IFNγ  a novel targeted gene therapeutic system for EBV positive human nasopharyngeal carcinoma. PLoS One. 2011 May 5;6(5):e19407.

35.     Song L, Gao S, Jiang W, Chen S, Liu Y, Zhou L, Huang W. Silencing suppressors  viral weapons for countering host cell defenses. Protein Cell. 2011 Apr;2(4):273-81.

36.     Wang H, Wu J, Meng X, Ying X, Zuo Y, Liu R, Pan Z, Kang T, Huang W. MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1. Carcinogenesis. 2011 Jul;32(7):1033-42.

37.     Zhang C, Liu H, Gao S, Huang W, Wang Z. [Polyethylenimine and minicircle DNA based gene transfer]. Sheng Wu Gong Cheng Xue Bao. 2010 Jun;26(6):772-9.

38.     Tan L, Xu B, Liu R, Liu H, Tan H, Huang W. Gene therapy for acute myeloid leukemia using Sindbis vectors expressing a fusogenic membrane glycoprotein. Cancer Biol Ther. 2010 Mar 1;9(5):350-7.

39.     Zhao P, Luo R, Wu J, Xie F, Li H, Xiao X, Fu L, Zhu X, Liu R, Zhu Y, Liang Z, Huang W. E10A, an adenovirus carrying human endostatin gene, in combination with docetaxel treatment inhibits prostate cancer growth and metastases. J Cell Mol Med. 2010 Jan;14(1-2):381-91.

40.     Liu H, Song L, Huang W. [MiR26a and miR939 regulate the replication of H1N1 influenza virus in MDCK cell]. Wei Sheng Wu Xue Bao. 2010 Oct;50(10):1399-405.

41.     Han H, Zhong C, Zhang X, Liu R, Pan M, Tan L, Li Y, Wu J, Zhu Y, Huang W. Genistein induces growth inhibition and G2/M arrest in nasopharyngeal carcinoma cells. Nutr Cancer. 2010;62(5):641-7.

42.     Zhang C, Gao S, Jiang W, Lin S, Du F, Li Z, Huang W. Targeted minicircle DNA delivery using folate-poly(ethylene glycol)-polyethylenimine as non-viral carrier. Biomaterials. 2010 Aug;31(23):6075-86.

43.     Yan H, Wu J, Liu W, Zuo Y, Chen S, Zhang S, Zeng M, Huang W. MicroRNA-20a overexpression inhibited proliferation and metastasis of pancreatic carcinoma cells. Hum Gene Ther. 2010 Dec;21(12):1723-34.

44.     Song L, Liu H, Gao S, Jiang W, Huang W. Cellular microRNAs inhibit replication of the H1N1 influenza A virus in infected cells. J Virol. 2010 Sep;84(17):8849-60.

45.     Wu J, Xiao X, Jia H, Chen J, Zhu Y, Zhao P, Lin H, Huang W. Dynamic distribution and expression in vivo of the human interferon gamma gene delivered by adenoviral vector. BMC Cancer. 2009 Feb 16;9:55.

46.     Zhang Y, Zhang Y, Guo S, Huang W. Tyrosine kinase inhibitor loaded PCL microspheres prepared by S/O/W technique using ethanol as pretreatment agent. Int J Pharm. 2009 Mar 18;369(1-2):19-23.

47.     Tan L, Jia H, Liu R, Wu J, Han H, Zuo Y, Yang S, Huang W. Inhibition of NF-kappaB in fusogenic membrane glycoprotein causing HL-60 cell death implications for acute myeloid leukemia. Cancer Lett. 2009 Jan 8;273(1):114-21.

48.     Jia HY, Wu JX, Zhu XF, Chen JM, Yang SP, Yan HJ, Tan L, Zeng YX, Huang W.ZD6474 inhibits Src kinase leading to apoptosis of imatinib-resistant K562 cells. Leuk Res. 2009 Nov;33(11):1512-9.

49.     Li Y, Shao JY, Liu RY, Zhou L, Chai LP, Li HL, Han HY, Huang BJ, Zeng MS,Zhu XF, Liu Q, Fu LW, Huang W. Evaluation of long-term toxicity of Ad/hIFN-, an Adenoviral vector encoding the human interferon-gamma gene, in nonhuman primates.Hum Gene Ther. 2008 Aug;19(8):827-39.

50.     Xue G, Liu RY, Li Y, Cheng Y, Liang ZH, Wu JX, Zeng MS, Tian FZ, Huang W. Dendritic cells modified with 6Ckine/IFNgamma fusion gene induce specific cytotoxic T lymphocytes in vitro. Cancer Immunol Immunother. 2007 Nov;56(11):1831-43.

51.     Huang BJ, Liu RY, Huang JL, Liang ZH, Gao GF, Wu JX, Huang W. Long-Term toxicity studies in Canine of E10A, an adenoviral vector for human endostatin gene. Hum Gene Ther. 2007 Mar;18(3):207-21.

52.     Zhao P, Zhu YH, Wu JX, Liu RY, Zhu XY, Xiao X, Li HL, Huang BJ, Xie FJ, Chen JM, Ke ML, Huang W. Adenovirus-mediated delivery of human IFNgamma gene inhibits prostate cancer growth. Life Sci. 2007 Aug 9;81(9):695-701.

53.     Huang J, Wang F, Argyris E, Chen K, Liang Z, Tian H, Huang W, Squires K, Verlinghieri G, Zhang H. Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med. 2007 Oct;13(10):1241-7.

54.     Li L, Liu RY, Huang JL, Liu QC, Li Y, Wu PH, Zeng YX, Huang W. Adenovirus-mediated intra-tumoral delivery of the human endostatin gene inhibits tumor growth in nasopharyngeal carcinoma. Int J Cancer. 2006 Apr 15;118(8):2064-71.

55.     Wu J, Xiao X, Zhao P, Xue G, Zhu Y, Zhu X, Zheng L, Zeng Y, Huang W. Minicircle-IFNgamma induces antiproliferative and antitumoral effects in human nasopharyngeal carcinoma. Clin Cancer Res. 2006 Aug 1;12(15):4702-13.

56.     Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W. Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome. Microbes Infect. 2005 Mar;7(3):427-36.

57.     He GA, Xue G, Xiao L, Wu JX, Xu BL, Huang JL, Liang ZH, Xiao X, Huang BJ, Liu RY, Huang W. Dynamic distribution and expression in vivo of human endostatin  gene delivered by adenoviral vector. Life Sci. 2005 Aug 5;77(12):1331-40.

58.     Liu RY, Wu LZ, Huang BJ, Huang JL, Zhang YL, Ke ML, Wang JM, Tan WP, Zhang RH, Chen HK, Zeng YX, Huang W. Adenoviral expression of a truncated S1 subunit of SARS-CoV spike protein results in specific humoral immune responses against SARS-CoV in rats. Virus Res. 2005 Sep;112(1-2):24-31.

59.     Huang W, Flint SJ. Unusual properties of adenovirus E2E transcription by RNA polymerase III. J Virol. 2003 Apr;77(7):4015-24.

60.     Huang W, Todaro L, Francesconi LC, Polenova T. 51V magic angle spinning NMR spectroscopy of six-coordinate Lindqvist oxoanions  a sensitive probe for the electronic environment in vanadium-containing polyoxometalates  Counterions dictate the 51V fine structure constants in polyoxometalate solids. J Am Chem Soc. 2003 May 14;125(19):5928-38.

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